PREDICTING THE NEED FOR VENTILATORY SUPPORT IN ORGANOPHOSPHORUS COMPOUND POISONING

Organophosphate Poisoning Predicting the Need for Mechanical Ventilator Support

Background: The easy availability and lack of legal strictures have made organophosphorus compound poisoning the deadly bane for the people of the lower socioeconomic strata, i.e., farmers and laborers. This study was conducted to predict the need for ventilator support in organophosphate poisoning and to identify the factors which help in predicting the need for ventilatory support in organoph...

Therapeutic effects of HESA-A (a herbal-marine compound) in acute organophosphorus pesticide poisoning

Objective: Organophosphorus compounds (OPs) are common causes of poisonings. Atropine and oximes are pharmacological antidotes of OPs. However, because of their adverse effects and insufficient performance, several other compounds have been evaluated as adjuvant therapy. HESA-A is a herbal-marine drug that contains material from Carum carvi (Persian cumin), Penaeus latisculatus...

Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning.

BACKGROUND The usefulness of a low butyrylcholinesterase (BuChE) activity on admission for predicting severity in acute organophosphorus (OP) insecticide poisoning has long been debated. Previous studies have been confounded by the inclusion of multiple insecticides with differing inhibitory kinetics. AIM We aimed to assess the usefulness of admission BuChE activity, together with plasma OP c...

Organophosphorus Compound Induced 'Intermediate Syndrome'

Organophosphorus poisoning (acute).

INTRODUCTION Acetylcholinesterase inhibition by organophosphorus pesticides or organophosphate nerve agents can cause acute parasympathetic system dysfunction, muscle weakness, seizures, coma, and respiratory failure. Prognosis depends on the dose and relative toxicity of the specific compound, as well as pharmacokinetic factors. METHODS AND OUTCOMES We conducted a systematic review and aimed...